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METHOD FOR C-KIT GENE L576P MUTATION DIAGNOSTIC IN MELANOMA TISSUE
METHOD FOR C-KIT GENE L576P MUTATION DIAGNOSTIC IN MELANOMA TISSUE
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机译:黑色素瘤组织中C-KIT基因L576P突变诊断的方法
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摘要
FIELD: biotechnology.;SUBSTANCE: invention is intended to diagnose the presence of c-KIT gene L576P mutation in melanoma tissues. Estimation of the presence of mutation is carried out according to the ratios of the values of Ct threshold cycles in three real-time PCR reactions with allele-specific primers. Based on the results of three duplicate reactions, the mutant DNA proportion in the sample is calculated.;EFFECT: invention provides optimisation of real-time allele-specific PCR for diagnosis of c-KIT L576P tyrosine kinase receptor mutation in melanoma tissues.;6 dwg, 1 tbl, 4 ex
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