首页> 外国专利> DRY POWDER COMPOSITIONS REPRESENTED AS PARTICLES WHICH CONTAIN TWO OR MORE ACTIVE INGREDIENTS FOR TREATMENT OF OBSTRUCTIVE OR INFLAMMATORY DISEASES OF RESPIRATORY WAYS

DRY POWDER COMPOSITIONS REPRESENTED AS PARTICLES WHICH CONTAIN TWO OR MORE ACTIVE INGREDIENTS FOR TREATMENT OF OBSTRUCTIVE OR INFLAMMATORY DISEASES OF RESPIRATORY WAYS

机译:含有两种或更多种活性成分的干粉组合物,用于治疗呼吸道阻塞性或炎症性疾病

摘要

FIELD: pharmacology.;SUBSTANCE: dry powder inhalation compositions containing spray-dried particles and their use for treatment of obstructive or inflammatory respiratory disease are described. Each particle has a core of the first active ingredient in a substantially crystalline form that is coated by a layer of the second active ingredient in a substantially amorphous form that is dispersed in a pharmaceutically acceptable hydrophobic excipient. The hydrophobic excipient is a phospholipid in an amount of 40 to 99 wt % of the composition. A method for preparation of such compositions and a delivery system comprising an inhaler and a dry powder composition are also described.;EFFECT: invention solves the problem of co-formulating two or more pharmaceutically active agents in a single powder dosage form that is suitable for inhalation, with improved aerosol characteristics.;15 cl, 3 dwg, 9 tbl, 7 ex
机译:领域:药理学;物质:描述了包含喷雾干燥颗粒的干粉吸入组合物及其在阻塞性或炎性呼吸道疾病治疗中的用途。每个颗粒具有基本结晶形式的第一活性成分的核心,该核心被分散在药学上可接受的疏水性赋形剂中的基本非晶形式的第二活性成分层覆盖。疏水性赋形剂是磷脂,其含量为组合物的40至99重量%。还描述了制备这种组合物的方法以及包括吸入器和干粉组合物的递送系统。效果:本发明解决了在单一粉末剂型中共同配制两种或更多种药物活性剂的问题,该剂型适合于吸入,具有改善的气溶胶特性。; 15 cl,3 dwg,9 tbl,7 ex

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