DRY POWDER COMPOSITIONS REPRESENTED AS PARTICLES WHICH CONTAIN TWO OR MORE ACTIVE INGREDIENTS FOR TREATMENT OF OBSTRUCTIVE OR INFLAMMATORY DISEASES OF RESPIRATORY WAYS

摘要

FIELD: pharmacology.;SUBSTANCE: dry powder inhalation compositions containing spray-dried particles and their use for treatment of obstructive or inflammatory respiratory disease are described. Each particle has a core of the first active ingredient in a substantially crystalline form that is coated by a layer of the second active ingredient in a substantially amorphous form that is dispersed in a pharmaceutically acceptable hydrophobic excipient. The hydrophobic excipient is a phospholipid in an amount of 40 to 99 wt % of the composition. A method for preparation of such compositions and a delivery system comprising an inhaler and a dry powder composition are also described.;EFFECT: invention solves the problem of co-formulating two or more pharmaceutically active agents in a single powder dosage form that is suitable for inhalation, with improved aerosol characteristics.;15 cl, 3 dwg, 9 tbl, 7 ex