NEW DISPIRO-INDOLINONES, MDM2/p53 INTERACTION INHIBITORS, METHOD FOR PRODUCTION AND APPLICATION

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to new derivatives of formula 1 dispiro-indolinones or pharmaceutically acceptable salts thereof, or optical isomers, where R₁ is selected from the group including phenyl optionally substituted with 1-2 substituents selected from halogen atom, lower alkoxy group; R₂ is selected from the group consisting of hydrogen, unsubstituted pyridyl or phenyl optionally substituted with a substituent selected from halogen, lower alkoxy, C₁-C₆alkyl or -O-C₅cycloalkyl; R₃ is selected from the group incuding a hydrogen or halogen atom; R₄ represents C₁-C₅alkyl; R₅ is selected from the group consisting of hydrogen, methyl or propargyl HC≡C-CH₂-. The invention also relates to the active ingredient, based on formula 1 compounda, pharmaceutical composition based of the said active ingredient, a drug based on this active ingredient or pharmaceutical composition, method for MDM2/p53 protein-protein interaction inhibition.;EFFECT: new dispiro-indolinone derivatives are obtained, that are useful for cancer treatment.;10 cl, 1 tbl, 15 ex