PHARMACEUTICAL COMPOSITION WITH PROLONGED ACTION OF GONADOTROPINS FOR INDUCTION OF SUPEROVULATION IN FEMALE MAMMALS

摘要

FIELD: pharmacology.;SUBSTANCE: invention is a composition comprising follicle-stimulating hormone (FSH) and luteinizing hormone (LH) at FSH/LH ratios (1/0.001-1/1) and a follicle stimulating hormone prolonging agent - a biologically degradable polyethylene glycol (PEG) polymer, characterized by additional content of 0.25-1% solution of novocaine, and PEG with a molecular weight of 6,000 to 70,000 Da is used as a prolongator, with the following proportions of components: FSH/LH (1/0.001-1/1) with an activity of 800-1000 IU in 0.25-1% solution of novocaine from 65 to 90 wt %; PEG with a weight of 6000 to 70,000 D, 10 to 35 wt %.;EFFECT: increased number of eggs suitable for fertilization.;2 tbl, 3 ex