Method of manufacture of the base of the chitosan hydrogel and polyelectrolytes charges negatively and porous material coming from said hydrogel alveolar

摘要

The invention relates to a method for the production of a hydrogel, comprising the following successive steps: a first step (i) of providing at least one powder of an anionic polymer (A) and at least one chitosan powder (B) including amine functions (-NH2); a second step (ii) consisting in the dry blending of at least the powders (A) and (B) from the first step in order to form a mixture of powders; a third step (iii) of suspending the powder mixture obtained at the end of the second step in an aqueous medium having a pH that allows the anionic polymer (A) to be solubilised without solubilising the chitosan (B); and a fourth step (iv) of adding an acid to the suspension obtained at the end of the third step so as to form the hydrogel. Alternatively, the third (iii) and fourth (iv) steps can be replaced by a fifth mixing step (v) comprising the mixing of: an acidified aqueous medium containing at least one compound (C) comprising at least one unit of a hexose or a unit derived from a hexose and/or at least one phosphate of said compound (C), with the mixture comprising at least the powders (A) and (B) obtained at the end of the second step (ii).