Use of heptyl glucoside as skin penetration enhancer in transdermal pharmaceutical compositions

摘要

A composition to be used for skin permeation, the composition comprising: 10-39% w/w heptyl glucoside; 1-10% w/w of an active pharmaceutical ingredient (API); and 60-89% w/w of an oil ester, wherein the heptyl glucoside is used as a natural solubilizer and as a skin permeation enhancer. Heptyl glucoside may enhance the solubility of the active pharmaceutical ingredient, thereby enhancing skin permeability to the active pharmaceutical ingredient, and is therefore useful in transdermal applications. The composition may be in a form selected from the group consisting of a liquid, cream, paste, gel, lotion, patch, tape, film former (e.g., plaster), and the like. Preferably the pharmaceutical ingredient is a hormone such as estradiol or estriol, and the oil ester is olive oil glycereth-8 ester.