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PIK3CA H1047R KNOCK-IN NON-HUMAN ANIMAL BREAST CANCER MODEL
PIK3CA H1047R KNOCK-IN NON-HUMAN ANIMAL BREAST CANCER MODEL
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机译:PIK3CA H1047R敲入非人类动物乳腺癌模型
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摘要
The invention concerns the development of a PIK3CA H1047R knock-in non-human animal breast cancer model, and its use for identification of a spontaneous loss-of-function TP53 mutation involved in spindle cell tumor formation. The invention further concerns the identification of additional somatic mutations and copy number aberrations in the breast tumors using this model, and methods and means for the diagnosis and treatment of breast cancer.
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