NOVEL NANOPARTICLE-BASED VACCINE TARGETING CANCER/TESTIS ANTIGENS (CTA) AND ITS USE IN SOLID AND HEMATOLOGICAL MALIGNANCIES

摘要

The present disclosure relates to antitumor vaccine compositions for oral administration. Disclosed herein are vaccine compositions comprising microparticles, wherein the particles comprise a gastric acid resistant, enteric erodable matrix comprising beta cyclodextrin and hydroxypropylmethyl cellulose acetate succinate (HPMCAS). The vaccine particles described herein encapsulate one or more cancer testis antigens (CTA), and an M-cell targeting lectin such as aleuria aurantia lectin (AAL), the lectin being present in a microfold cell (M-cell) targeting effective amount; and an aqueous vehicle in which said nanoparticles are suspended. In another aspect the present disclosure relates to assemblies of the microparticles themselves. Lastly, disclosed are methods of treating cancer by immunizing subjects in need of treatment with the foregoing vaccine compositions.