LOW TEMPERATURE FREE RADICAL INITIATED PROCESS FOR THE PREPARATION OF 3-((3,3,3-TRIFLUOROPROPYL)THIO)PROPIONIC ACID AND ESTERS THEREOF

摘要

3-((3,3,3-Trifluoropropyl)thio)propionic acid and esters thereof are prepared by a low temperature free radical process involving the free radical coupling of 3-mercaptopropionic acid and esters thereof with 3,3,3-trifluoropropene. The ratio of linear to branched isomer is enhanced.