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METHOD FOR QUANTITATIVE ANALYSIS OF HIGH-MOLECULAR-WEIGHT COMPOUND, AND DATA PROCESSING DEVICE FOR SAID QUANTITATIVE ANALYSIS
METHOD FOR QUANTITATIVE ANALYSIS OF HIGH-MOLECULAR-WEIGHT COMPOUND, AND DATA PROCESSING DEVICE FOR SAID QUANTITATIVE ANALYSIS
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机译:高分子化合物的定量分析方法及所述定量分析的数据处理装置
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摘要
An analysis operator enters the structures of sugar chains assumed to be contained in a sample, assumed ionic numbers, m/z of a common product ion, etc. Then, a precursor m/z calculator (301) calculates the m/z of precursor ions originating from each sugar chain. A method file creator (305) prepares a method file including MRM transitions. A multivalent ion information file creator (303) creates a file which associates a unique ID of each sugar-chain structure with m/z of precursor ions and m/z of a product ion. After the completion of a measurement, a chromatogram creator (34) creates a mass chromatogram for each MRM transition. A peak area totalizer (311) refers to the association file and adds up peak areas on mass chromatograms obtained for a plurality of MRM transitions corresponding to the same sugar chain. Based on the calculated total values, a quantitative value calculator (312) calculates an abundance ratio of each sugar chain as a quantitative value. A quantitative output information creator (39) graphically displays the quantitative values on a display unit (5). By such a method, a simultaneous multicomponent analysis of sugar chains or similar compounds from which multivalent ions are easily generated can be performed using an LC-MS.
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