GENETIC POLYMORPHISMS ASSOCIATED WITH STATIN RESPONSE AND CARDIOVASCULAR DISEASES, METHODS OF DETECTION AND USES THEREOF

摘要

The invention provides a method for predicting responsiveness to statin treatment for reducing coronary heart disease (CHD) risk in a human, the method comprising testing a sample of nucleic acid from said human for the presence or absence of a single nucleotide polymorphism (SNP) in the nucleotide sequence of SEQ ID NO:3495 (rs1538185), wherein said human is determined to have an increased responsiveness to statin treatment for reducing CHD risk due to the presence of G at position 101 of SEQ ID NO:3495 or the presence of C at position 101 of its complement. Further provided are uses of a detection reagent and a kit for predicting said statin responsiveness in a human. The invention also provides said statin or a therapeutic agent for use in a method of treatment of CHD based on the detection of said SNP in the nucleotide sequence of SEQ ID NO:3495.