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SYNTHETIC SINGLE GUIDE RNA FOR CAS9-MEDIATED GENE EDITING
SYNTHETIC SINGLE GUIDE RNA FOR CAS9-MEDIATED GENE EDITING
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机译:用于CAS9介导的基因编辑的合成单指导RNA
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摘要
The present invention provides synthetic single guide RNAs that comprise two separate functional sequences (commonly known as crRNA and tracrRNA) connected by a linker. These synthetic single guide RNA molecules are useful in gene editing when used with RNA-guided endonucleases such as cas9 in eukaryotic cells. The availability of the synthetic single guide RNAs makes the screening for gene editing in high-through-put format simple and convenient.
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