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UNNATURAL AMINO ACIDS COMPRISING A NORBORNENYL GROUP AND USES THEREOF

机译：包含诺博尼集团的不饱和氨基酸及其用途

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摘要

The present invention relates to unnatural amino acids comprising a norbornenyl group and having formulaor an acid or base addition salt thereof.;The invention also relates to the use of said unnatural amino acids and processes for preparation of polypeptides that comprise one or more than one norbornenyl group. These polypeptides can be covalently modified by in vitro or in vivo reaction with compounds comprising a 1,2,4,5-tetrazine group.

机译：本发明涉及包含降冰片烯基并具有下式的非天然氨基酸 <图像文件=“ IMGA0001.GIF” he =“ 15” imgContent =“ chem” imgFormat =“ GIF” wi =“ 72” /> 本发明还涉及所述非天然氨基酸的用途和用于制备包含一个或多个一个降冰片烯基的多肽的方法。这些多肽可通过与包含1,2,4,5-四嗪基团的化合物的体外或体内反应进行共价修饰。 展开▼

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公开/公告号EP3279211A1

专利类型

公开/公告日2018-02-07

原文格式PDF

申请/专利权人 EMBL;
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申请/专利号EP20170176529

发明设计人 LEMKE EDWARD;SCHULTZ CARSTEN;PLASS TILMAN;MILLES SIGRID;KOEHLER CHRISTINE;
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申请日2012-02-03

分类号C07K14;C07C11;C07C11/22;

国家 EP

入库时间 2022-08-21 13:14:40

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