HUMANIZED ANTIBODY FOR TREATING OR PREVENTING DEMENTIA AND PRODUCTION METHOD THEREFOR AND THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR DEMENTIA USING SAME

摘要

PROBLEM TO BE SOLVED: To provide a humanized anti-phosphorylated tau antibody applicable as a therapeutic or prophylactic agent for dementia such as tauopathy in humans with reduced antigenicity to humans without substantially impairing the binding properties of mouse monoclonal anti-phosphorylated tau antibody to phosphorylated tau.SOLUTION: A humanized antibody or a fragment thereof that undergoes an antigen-antibody reaction with tau protein or tau peptide phosphorylated at least by an amino acid residue corresponding to Ser 413 among specific amino acid sequences, or a derivative thereof.SELECTED DRAWING: Figure 3