MUCUS-PENETRATING COATED PARTICLES, COMPOSITIONS, PHARMACEUTICAL COMPOSITION, PHARMACEUTICAL FORMULATIONS, AND METHODS OF FORMING THEM

摘要

PROBLEM TO BE SOLVED: To provide compositions that improve particle transport in mucus.SOLUTION: A composition comprises a plurality of coated particles each comprising: a core particle comprising a pharmaceutical or a salt thereof; and a coating comprising a surface-altering agent surrounding the core particle. The surface-altering agent comprises a synthetic polymer having pendant hydroxyl groups on the backbone of the polymer. The polymer having a molecular weight from about 1 kDa to about 1000 kDa inclusive. The polymer is at least about 30% and less than about 95% hydrolyzed. The coated particles have relative velocity greater than 0.5 in mucus.SELECTED DRAWING: None