PHARMACEUTICAL COMPOSITIONS COMPRISING CONVENTIONAL LIPOSOMES AND PROLONGED CIRCULATION LIPOSOMES FOR TREATING VISCERAL LEISHMANIASIS

摘要

PROBLEM TO BE SOLVED: To provide pharmaceutical compositions comprising conventional liposomes and prolonged circulation liposomes for treating visceral leishmaniasis.SOLUTION: The invention relates to a pharmaceutical composition for treating visceral leishmaniasis, characterized in that it comprises the association of conventional liposomes and prolonged-circulation liposomes with a leishmanicidal-drug delivery system. The composition may be used in the preparation of a medicinal product for treating leishmanial syndromes and may be administered intramuscularly, subcutaneously, intraperitoneally or intravenously. The use of this system enables efficient reach of the drug to all sites infected by the parasite, where the PEGylated liposomes promote more effective targeting of the leishmanicidal drugs on the bone marrow and spleen, whilst the conventional liposomes contribute to the targeting of the drug on the liver.SELECTED DRAWING: None