COMPOSITIONS AND METHODS FOR REGULATING NK CELL ACTIVITY

摘要

PROBLEM TO BE SOLVED: To provide novel compositions for regulating immune response in subjects and preparation methods thereof.SOLUTION: Disclosed herein is a method for preparing an antibody that cross-reacts with a plurality of KIR2DL gene products to neutralize the inhibitory activity of such KIRs, the method comprising the steps of: (a) immunizing a non-human mammal with an immunogen comprising a KIR2DL polypeptide; (b) preparing antibodies that bind to the KIR2DL polypeptide from the immunized mammal; (c) selecting antibodies of (b) that cross-react with at least two different KIR2DL gene products; (d) selecting antibodies of (c) that potentiate NK cells; and (e) selecting an antibody that binds to a primate NK cell or KIR polypeptide.SELECTED DRAWING: None