Heat-stable human epidermal growth factor-spider toxin fusion protein with increased skin cell proliferation effect and cosmetic composition for improving skin wrinkles and maintaining skin elasticity containing the same as an active ingredient

摘要

The present invention comprises a heat-stable human epidermal growth factor-spider toxin fusion protein having an increased proliferation effect of skin cells consisting of the amino acid sequence of SEQ ID NO: 2, a base sequence of SEQ ID NO: 1 optimized for E. coli codon. A gene encoding a fusion protein of human epidermal growth factor-spider venom, a recombinant vector containing the gene, a host cell transformed with the recombinant vector, and a human epithelium by transforming the host cell with the recombinant vector The present invention relates to a method for producing a fusion protein of cell growth factor-spider venom and a cosmetic composition for improving skin wrinkles and maintaining skin elasticity comprising human epidermal growth factor-spider venom fusion protein as an active ingredient. Since the cosmetic composition of the invention is excellent in thermal stability and can improve skin wrinkle improvement and skin elasticity maintenance effect, functional cosmetics in the future It can be usefully used in the field or cosmetic surgery field.