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COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING ANEMIA

机译:诊断和治疗贫血的组合物和方法

摘要

PROBLEM TO BE SOLVED: To provide pharmaceutical compositions for treating or preventing anemia conditions such as hemolytic anemia, thalassemias, hereditary spherocytosis, hereditary elliptocytosis, glucose-6-phosphate dehydrogenase deficiency, pyruvate kinase deficiency, immune hemolytic anemia, alloimmune hemolytic anemia, drug-induced hemolytic anemia, mechanical hemolytic anemias.SOLUTION: The invention provides a pharmaceutical composition comprising one or more fatty acids or pharmaceutically acceptable salt thereof in the proviso that the one or more fatty acids is selected from the group consisting of odd chain fatty acids and very long even chain fatty acids, and a pharmaceutically acceptable carrier. In one embodiment, the one or more fatty acids is heptadecanoic acid. In one embodiment, the composition is substantially free from even chain fatty acids. In one embodiment, the composition comprises at least one odd chain fatty acid and at least one very long even chain fatty acid. In one embodiment, the one or more fatty acids comprises heptadecanoic acid and behenic acid.SELECTED DRAWING: None
机译:要解决的问题:提供用于治疗或预防贫血状况的药物组合物,例如溶血性贫血,地中海贫血,遗传性球形细胞增多症,遗传性脂细胞增多症,6-磷酸葡萄糖脱氢酶缺乏症,丙酮酸激酶缺乏症,免疫溶血性贫血,同种免疫溶血性贫血,药物诱导的溶血性贫血,机械性溶血性贫血。解决方案:本发明提供一种药物组合物,其包含一种或多种脂肪酸或其药学上可接受的盐,条件是该一种或多种脂肪酸选自奇链脂肪酸和非常多的脂肪酸。长且均匀的链状脂肪酸,以及药学上可接受的载体。在一个实施方案中,一种或多种脂肪酸是十七烷酸。在一个实施方案中,该组合物基本上不含偶链脂肪酸。在一个实施方案中,该组合物包含至少一种奇数链脂肪酸和至少一种非常长的偶数链脂肪酸。在一个实施方案中,一种或多种脂肪酸包括十七烷酸和山hen酸。

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