PHARMACEUTICAL COMPOSITION FOR USE IN PREVENTION AND/OR TREATMENT OF BLOOD COAGULATION FACTOR XI (FXI) ABNORMALITIES COMPRISING MULTISPECIFIC ANTIGEN BINDING MOLECULE REPLACING FUNCTION OF BLOOD COAGULATION FACTOR VIII (FVIII)

摘要

PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for use in the prevention and/or treatment of blood coagulation factor XI (FXI) abnormalities.SOLUTION: A pharmaceutical composition for use in the prevention and/or treatment of blood coagulation factor XI abnormalities comprising a multispecific antigen binding molecule replacing the function of blood coagulation factor VIII. The multispecific antigen binding molecule replacing the function of blood coagulation factor VIII is a bispecific antibody that binds to blood coagulation factor IX and/or active coagulation factor IX and blood coagulation factor X.EFFECT: The multispecific antigen binding molecule replacing the function of blood coagulation factor VIII, can be used not only for preventing and/or treating bleeding resulting from FVIII dysfunction in hemophilia A, acquired Hemophilia A, and von Willebrand disease, but can also be used for preventing and/or treating bleeding due to diseases related to an abnormality in blood coagulation factor XI by the coagulation promoting action thereof.SELECTED DRAWING: None