Botulinum toxin-human epidermal growth factor fusion protein with enhanced proliferation and antioxidant effect of skin cells, and cosmetic composition for skin regeneration and wrinkle improvement containing the same as an active ingredient

摘要

The present invention relates to a fusion protein of botulinum toxin-human epithelial cell growth factor, which has an increased proliferation and antioxidant effect of the skin cell consisting of the amino acid sequence of SEQ ID NO: 2, from the nucleotide sequence of SEQ ID NO: 1 optimized for the gonococcal codon A gene encoding a fusion protein of botulinum toxin-human epithelial cell growth factor, a recombinant vector containing the gene, a host cell transformed into the recombinant vector, a botulinum toxin-human transformed into the recombinant vector The present invention relates to a method for producing an epidermal growth factor fusion protein, and a cosmetic composition for improving skin wrinkles and maintaining skin elasticity, comprising a botulinum toxin-human epidermal growth factor fusion protein as an active ingredient. Since the cosmetic composition can improve skin wrinkles and enhance the skin regeneration effect, it will be used in the functional cosmetic field in the future. It can be used as useful in cosmetic molding field.