POLYMORPHS OF BROMFENAC SODIUM AND METHODS FOR PREPARING BROMFENAC SODIUM POLYMORPHS

摘要

PROBLEM TO BE SOLVED: To provide: novel polymorphs of bromfenac sodium [a sodium salt of 2-amino-3-(4-bromobenzoyl)phenylacetic acid, which is used as eye drops known as a non-steroidal anti-inflammatory drug with analgesic effect; novel, reproducible processes for their preparation; and pharmaceutical compositions containing such polymorphs.SOLUTION: The invention provides bromfenac sodium, characterized by a powder x-ray diffraction pattern having main peaks expressed as 2-θ at about 16.5, 18.5, 20.7, 34.1, 11.3, 14.4, 17.3, 19.4, 21.0, 22.7, 29.0, 31.8, and 36.1°.SELECTED DRAWING: None