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Method for preparing hydrogel comprising chitosan and negatively charged polyelectrolyte and cellular porous material obtained from said hydrogel

机译:包含壳聚糖和带负电的聚电解质的水凝胶的制备方法以及由所述水凝胶获得的细胞多孔材料

摘要

The present invention relates to a method for producing a hydrogel,Continuously include the following steps: A powder of at least one anionic polymer (A) and an amine functional group (-NH2A first step (i) of providing at least one chitosan (B) powder comprising at least one chitosan (B) A second step (ii) consisting of at least dry mixing the powder (A) obtained from the first step and the powder (B) to form a powder mixture, The powder mixture obtained from the second step is suspended in an aqueous medium having a pH that makes it possible to dissolve the anionic polymer (A) without dissolving the chitosan (B) A third step (iii) A fourth step (iv) of adding an acid to the suspension obtained from the third step to form the hydrogel, Wherein the third step (iii) and the fourth step (iv) comprise at least one compound (C) comprising at least one hexose unit or a unit derived from a hexose and / or at least one compound (C) (V) a fifth mixing step (v) comprising mixing an acidified aqueous medium containing an acid salt with the mixture comprising at least the (A) powder and the (B) powder obtained from the second step (ii) In the presence of a catalyst.
机译:本发明涉及一种水凝胶的制备方法,其连续包括以下步骤:至少一种阴离子聚合物(A)和胺官能团(-NH <2 )的粉末第一步(i) )提供至少一种包含至少一种壳聚糖(B)的壳聚糖(B)粉末。第二步(ii)由将第一步中获得的粉末(A)与粉末(B)至少干混以形成将由第二步骤获得的粉末混合物悬浮在具有能够溶解阴离子聚合物(A)而又不溶解脱乙酰壳多糖(B)的pH的水性介质中。第三步骤(iii)第四步骤(iv) )向第三步获得的悬浮液中加入酸以形成水凝胶,其中第三步(iii)和第四步(iv)包含至少一种化合物(C),其包含至少一个己糖单元或衍生的单元来自己糖和/或至少一种化合物(C)(V)的第五混合步骤(v),包括混合含有酸盐的酸化含水介质,以及在催化剂的存在下,该混合物至少包含由第二步骤(ii)获得的(A)粉末和(B)粉末的混合物。

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