PROBLEM TO BE SOLVED: To provide PLGA microparticles suitable for filtration sterilization.;SOLUTION: A PLGA microparticle contains lactic acid-glycolic acid copolymer (PLGA), in which relative Span Factor (R. S. F.) satisfies a formula (1) and an average volume-based particle diameter is 80 nm or less. 0(R. S. F.)≤1.20...formula (1) [(R. S. F.) is defined by (D90-D10)/D50, D90 represents a cumulative 90 volume% from the small particle side of the cumulative particle size distribution, D50 represents a cumulative 50 volume% from the small particle side of the cumulative particle size distribution, D10 represents a cumulative 10 volume% from the small particle side of the cumulative particle size distribution.];SELECTED DRAWING: Figure 6;COPYRIGHT: (C)2018,JPO&INPIT
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