MEDICAL DRUG COMPOSITE, POLYMER CARRIER, METHOD FOR PRODUCING SAME, AND THERAPEUTIC AGENT OF CANCER, RHEUMATISM OR INFLAMMATION

摘要

PROBLEM TO BE SOLVED: To provide a medical drug composite that has high introduction rate of a pharmaceutical compound per high-molecular substance, can be prepared with good purity in mild conditions, is stable in blood, but can release the pharmaceutical compound at the site of cancer, rheumatism, inflammation, etc.SOLUTION: The medical drug composite is expressed by the formula GP-(CONH-X-CONHN=DG): [in the formula, GP is GP-(COH), and denotes a high-molecular substance having a weight average molecular weight of 30,000 or more and a carboxyl group. Reference code n denotes a positive integer, and X denotes a spacer. DG is DG=O, and denotes a pharmaceutical compound having a carbonyl group].SELECTED DRAWING: Figure 1