METHOD OF CULTURING LYMPHOCYTE HAVING IMPROVED CYTOTOXIC ACTIVITY, AND CELLULAR IMMUNOLOGICAL THERAPEUTIC AGENT CONTAINING LYMPHOCYTE HAVING IMPROVED CYTOTOXIC ACTIVITY OBTAINED BY THE METHOD

摘要

PROBLEM TO BE SOLVED: To provide a method of culturing a lymphocyte having improved cytotoxic activity, and a cellular immunological therapeutic agent containing a lymphocyte having improved cytotoxic activity obtained by the method.;SOLUTION: The inventors have completed the invention by discovering the new fact that: a lymphocyte, which is obtained by adding an anti-PD-1 antibody to a lymphocyte after cultured for 1-20 days, and removing the antibody several hours after the addition, has high cytotoxic activity and also has anticancer effect in low concentrations.;SELECTED DRAWING: None;COPYRIGHT: (C)2018,JPO&INPIT