How to assess the risk of drug side effects induced by phenytoin

摘要

PROBLEM TO BE SOLVED: To provide methods for predicting the risk of drug adverse effects caused by phenytoin including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic syndrome (DRESS), or maculopapular eruption (MPE).SOLUTION: The invention is characterized by comprising detecting the presence of an HLA allele including HLA-A, HLA-B, and HLA-DRB1, and associating the presence of an HLA allele as a factor that increases the risk of drug adverse effects caused by phenytoin including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug rash with eosinophilia and systemic syndrome (DRESS), or maculopapular eruption (MPE).SELECTED DRAWING: Figure 1