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Method for identifying strains of Mycobacterium tuberculosis and method for detecting gene mutation

机译:结核分枝杆菌菌株的鉴定方法和基因突变的检测方法

摘要

[Problem] To provide a method for identifying a strain of Mycobacterium tuberculosis, etc. in a sample and detecting a gene variation using the gene sequence information thereof. [Solution] By composing a consensus genome consisting of a plurality of M. tuberculosis strains and analogous strains thereof, acquiring gene sequence information of a strain in a sample, and then comparison processing the same to the consensus genome, the strain can be identified and, at the same time, a gene variation in the strain can be detected. The consensus genome can be composed by correcting inversions in the genes of the M. tuberculosis strains and analogous strains thereof.
机译:[问题]提供一种用于鉴定样品中的结核分枝杆菌等的菌株并使用其基因序列信息检测基因变异的方法。 [解决方案]通过组合由多个结核分枝杆菌菌株及其类似菌株组成的共有基因组,获取样品中菌株的基因序列信息,然后将其与共有基因组进行比较处理,可以鉴定出该菌株并鉴定出该菌株。同时,可以检测到菌株中的基因变异。共有基因组可以通过校正结核分枝杆菌菌株及其类似菌株的基因中的倒位来组成。

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