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Antibodies that recognize deletion mutants of epidermal growth factor receptor and uses thereof

机译:识别表皮生长因子受体的缺失突变体的抗体及其用途

摘要

The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
机译:本发明涉及新型抗体,特别是针对表皮生长因子受体的缺失突变体的抗体,尤其是III型缺失突变体EGFRvIII。本发明还涉及针对表皮生长因子受体的缺失突变体的人单克隆抗体,尤其涉及EGFRvIII。还提供了此类抗体的诊断和治疗制剂及其免疫缀合物。

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