IL13Rα2 binding agents and their use in cancer therapy

摘要

Provided are specific binding molecules or fragments thereof that bind to an epitope of IL13Rα2, a receptor polypeptide that is preferentially found on the surface of cancer cells but not healthy cells. Exemplary specific binding molecules include a fragment of an IL13Rα2 binding molecule and a signal transduction function of the signaling domain of a T cell signaling protein, a peptide modulator of T cell activation or an enzyme component of a labeling system. A bispecific binding molecule comprising a peptide that provides a function. Also provided are polynucleotides, vectors, host cells, pharmaceutical compositions, and solid tumor diseases (eg, polymorphisms) that encode such specific binding molecules (eg, bispecific binding molecules). A method of preventing, treating or ameliorating symptoms associated with cancer diseases such as glioblastoma). [Selection] Figure 1