Multivalent CD20 binding molecules comprising Shiga toxin A subunit effector region and their enhanced compositions

摘要

The present invention provides multivalent CD20 binding molecules and compositions thereof, eg, reinforcing compositions comprising a large proportion of multivalent CD20 binding molecules compared to monovalent CD20 binding molecules. Certain multivalent CD20 binding molecules of the invention include 1) two or more CD20 binding regions, and 2) one or more Shiga toxin effectors derived from the A subunit of members of the Shiga toxin family. Contains a polypeptide region. Certain multivalent CD20 binding molecules of the invention, and compositions thereof, are used for the selective killing of specific cell types and also treat various diseases including cancer, tumors and immune disorders Used as a remedy for. Certain multivalent CD20 binding molecules and compositions thereof of the present invention can be used for various diseases such as cancer, tumors and immune disorders involving intracellular labeling of CD20 expressing cells, collection of diagnostic information, and CD20 expressing cells. It is used for the delivery of drugs to CD20-expressing cells for the purpose of monitoring the treatment of CD20.