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Method for screening compounds for treating and / or preventing diseases in which aggregates of TDP-43 accumulate
Method for screening compounds for treating and / or preventing diseases in which aggregates of TDP-43 accumulate
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机译:筛选用于治疗和/或预防TDP-43聚集的疾病的化合物的方法
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摘要
PROBLEM TO BE SOLVED: To provide a TDP-43 variant having agglomerate forming ability and cytotoxicity in the whole length sequence; and a screening method of a compound for therapy and/or prevention of TDP-43 agglomerate-accumulating diseases by utilizing the TDP-43 variant.SOLUTION: A TDP-43 variant comprises an amino acid sequence with a cysteine at the 173 and/or 175 positions being substituted in TDP-43 amino acid sequence. A screening method of a compound for therapy and/or prevention of TDP-43 agglomerate-accumulating diseases comprises the following steps of: (1) bringing the TDP-43 variant into contact with a compound as a candidate; (2) detecting agglomerate formation inhibitory activity of the compound; and (3) selecting a compound inhibiting agglomerate formation.
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