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Transformed filamentous fungus having enhanced ability to produce ergothioneine and method for producing ergothioneine
Transformed filamentous fungus having enhanced ability to produce ergothioneine and method for producing ergothioneine
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机译:具有增强的生产麦角硫氨酸能力的转化丝状真菌和生产麦角硫氨酸的方法
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摘要
The purpose of the present invention is to provide an organism having an ergothioneine productivity that is capable of easily producing ergothioneine within a short period of time at a high yield, as compared with a conventional technology, and, therefore, enables ergothioneine production on an industrial scale. This purpose can be achieved by a transformed fungus into which a gene encoding enzyme (1) or genes encoding enzymes (1) and (2) have been inserted and in which the inserted gene (s) are overexpressed. (1) an enzyme catalyzing a reaction of synthesizing hercynyl cysteine sulfoxide from histidine and cysteine in the presence of S-adenosyl methionine, iron (II) and oxygen. (2) An enzyme catalyzing a reaction of synthesizing ergothioneine from hercynyl cysteine sulfoxide using pyridoxal 5'-phosphate as a coenzyme.
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