首页>
外国专利>
Use of modulators of compounds of the TGF-β superfamily to control iron metabolism by hepcidin
Use of modulators of compounds of the TGF-β superfamily to control iron metabolism by hepcidin
展开▼
机译:TGF-β超家族化合物的调节剂在铁调素控制铁代谢中的应用
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-² superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.
展开▼