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Intracellular introduction agent of target protein and intracellular introduction method of target protein

机译:靶蛋白的细胞内导入剂及靶蛋白的细胞内导入方法

摘要

PROBLEM TO BE SOLVED: To provide an intracellular introduction agent of target protein which has low toxicity to a cell, has a high introduction efficiency of a target protein into a cell, and can readily release the target protein from a carrier (intracellular introduction agent) after the intracellular introduction of the target protein, to provide a nucleic acid encoding the intracellular introduction agent, and to provide an intracellular introduction method of the target protein using the intracellular introduction agent.SOLUTION: The invention provides an intracellular introduction agent of a target protein consisting of a polypeptide consisting of an amino acid sequence of a formula (1), or a variant thereof; a nucleic acid encoding the intracellular introduction agent; and an intracellular introduction method of the target protein using the intracellular introduction agent. Amino acid sequence: X-Y-Z...(1) (X, Y, and Z represent each independently a specific amino acid sequence, and n is integer of 1-8)
机译:解决的问题:提供一种靶蛋白的细胞内导入剂,该靶蛋白对细胞的毒性低,将靶蛋白导入细胞的效率高,并且可以容易地从载体中释放靶蛋白(细胞内导入剂)在胞内导入靶蛋白后,提供编码胞内导入剂的核酸,并提供了使用胞内导入剂对靶蛋白进行胞内导入的方法。解决方案:本发明提供了一种靶蛋白的胞内导入剂。由由式(1)的氨基酸序列或其变体组成的多肽组成;编码细胞内引入剂的核酸;以及使用细胞内导入剂的靶蛋白的细胞内导入方法。氨基酸序列:X-Y-Z ...(1)(X,Y和Z分别独立表示特定的氨基酸序列,n为1-8的整数)

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