Method for producing a bone regeneration material comprising biodegradable fibers using electrospinning

摘要

A new method for producing a bone regeneration material containing calcium phosphate particles in a biodegradable fiber made of PLGA with electrospinning and a new bone regeneration material produced by the method. Is required. PLGA resin softened by heating PLGA resin in a kneader to soften the resin until the viscosity of the resin reaches 102 to 107 Pa · s, and then adding powder of calcium phosphate fine particles while rotating the blades of the kneader. The mixture is kneaded by applying thermal and mechanical energy to the mixture by continuously rotating the blades of the kneader in the heated state, and the aggregates of the calcium phosphate particles are crushed, whereby the calcium phosphate particles In a solution in which the PLGA resin is completely dissolved by the solvent and the calcium phosphate fine particles are dissolved in the PLGA resin. A spinning solution that is dispersed without agglomerating with Calcium acid particles to produce the biodegradable fibers that are substantially uniformly dispersed in a biodegradable fibers.