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Method for identifying treatment-responsive non-small cell lung cancer using anaplastic lymphoma kinase (ALK) as a marker
Method for identifying treatment-responsive non-small cell lung cancer using anaplastic lymphoma kinase (ALK) as a marker
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机译:用间变性淋巴瘤激酶(ALK)为标志物识别治疗反应性非小细胞肺癌的方法
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摘要
Disclosed herein are methods for identifying a subject as having NSCLC that is predicted or is likely to respond to treatment with an ALK inhibitor, for example crizotinib. The methods include identifying a sample including NSCLC tumor cells as ALK-positive or ALK-negative using immunohistochemistry (IBC) and scoring methods disclosed herein. A subject is identified as having NSCLC likely to respond to treatment with an ALK inhibitor if the sample is identified as ALK-positive and is identified as having NSCLC not likely to respond to treatment with an ALK inhibitor if the sample is identified as ALK-negative. According to certain embodiments of the methods, subjects predicted to respond to an ALK inhibitor may then be treated with an ALK inhibitor such as crizotinib.
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