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Heat shock protein 70 (hsp-70) receptor ligands
Heat shock protein 70 (hsp-70) receptor ligands
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机译:热激蛋白70(hsp-70)受体配体
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摘要
Inducible HSP70 is overexpressed in a wide spectrum of human tumors and its expression correlates with metastasis and poor outcomes to radiation and chemotherapy in patients. Identification of small molecule inhibitors of HSP70 pose a new therapy to cancer treatment. HS72, a benzimidazole piperidinyl carboxamide has been identified as an allosteric inhibitor for HSP70 and has demonstrated good tumor growth inhibition in vivo.
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