首页> 外国专利> PHARMACEUTICAL COMPOSITION FOR TREATING CANCER INCLUDING 2-METHOXY-4-(3-(4-METHOXYPHENYL)PROP-1-EN-1-YL)PHENOL AS ACTIVE INGREDIENT

PHARMACEUTICAL COMPOSITION FOR TREATING CANCER INCLUDING 2-METHOXY-4-(3-(4-METHOXYPHENYL)PROP-1-EN-1-YL)PHENOL AS ACTIVE INGREDIENT

机译:用于治疗癌症的药物组合物,其中包括作为活性成分的2-甲氧基-4-(3-(4-甲氧基苯基)丙-1-烯-1-基)苯酚

摘要

The present disclosure relates to an anticancer use of a novel compound, i.e., 2-methoxy-4-(3-(4-methoxyphenyl)propyl-1-en-1-yl)phenol. The compound of the present disclosure effectively inhibits the growth of cancer cells and tumors in vitro and in a xenograft animal model. The compound of the present disclosure illustrates an anticancer activity by inhibiting a DNA binding activity of transcription factor STAT 3 in cancer cells, inducing apoptosis of cancer cells, and reducing the expression of a cell cycle regulatory protein. The compound of the present disclosure can be developed as an active ingredient of a strong anticancer drug.
机译:本公开涉及新型化合物,即2-甲氧基-4-(3-(4-甲氧基苯基)丙基-1-烯-1-基)苯酚的抗癌用途。本公开的化合物在体外和异种移植动物模型中有效抑制癌细胞和肿瘤的生长。本公开的化合物通过抑制癌细胞中转录因子STAT 3的DNA结合活性,诱导癌细胞的凋亡并减少细胞周期调节蛋白的表达来说明抗癌活性。本公开的化合物可以被开发为强抗癌药的活性成分。

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