首页> 外国专利> Nanoparticles, Composed of Sterol and Saponin From Quillaja Saponaria Molina Process for Preparation and Use Thereof as Carrier for Amphipatic of Hydrophobic Molecules in Fields of Medicine Including Cancer Treatment and Food Related Compounds

Nanoparticles, Composed of Sterol and Saponin From Quillaja Saponaria Molina Process for Preparation and Use Thereof as Carrier for Amphipatic of Hydrophobic Molecules in Fields of Medicine Including Cancer Treatment and Food Related Compounds

机译:由Quillaja Saponaria Molina工艺中的甾醇和皂苷组成的纳米颗粒,用于制备和用作疏水性分子的两性载体,在包括癌症治疗和食品相关化合物在内的医学领域

摘要

A nanoparticle comprising at least one sterol, e.g. cholesterol and a component from Quillaja Saponaria Molina (QuilQ) selected from quillaja saponin, characterized in that said nanoparticles do not comprise a phospholipid and in that the sterol molecule is bound by a hydrophobic bond between a hydroxyl group of the sterol and terpene moieties in a Quil A micelle and by an hydrophilic ester bond between a sterol OH and COOH or aldehyde groups in the QuilA micelle. It also relates to a composition comprising the nanoparticles, and the use thereof as carriers for amphipathic or hydrophobic molecules and as agents for treatment of cancer. Further, it regards a method for producing the phospholipid-free nanoparticles, a method for the treatment of cancer and a method for assessing the applicability of the cancer treating method.
机译:包含至少一种固醇的纳米颗粒,例如,胆固醇和选自Quillaja Saponin的Quillaja Saponaria Molina(QuilQ)的组分,其特征在于,所述纳米颗粒不包含磷脂,并且固醇分子通过固醇的羟基和萜烯部分中的疏水基团之间的疏水键结合。 QuilA胶束和QuilA胶束中的固醇OH -和COOH -或醛基之间的亲水酯键。它还涉及包含纳米颗粒的组合物,及其作为两亲或疏水分子的载体和作为癌症治疗剂的用途。此外,其涉及用于生产无磷脂纳米颗粒的方法,用于治疗癌症的方法以及用于评估该癌症治疗方法的适用性的方法。

著录项

  • 公开/公告号US2018104330A1

    专利类型

  • 公开/公告日2018-04-19

    原文格式PDF

  • 申请/专利权人 MOREINX AB;

    申请/专利号US201715844152

  • 发明设计人 BROR MOREIN;SAIDEH BERENJIAN;KEFEI HU;

    申请日2017-12-15

  • 分类号A61K39/39;G01N33/50;A61K39/145;

  • 国家 US

  • 入库时间 2022-08-21 13:05:24

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