Use of iron oxide nanoparticle in inhibiting spore germination of clostridium difficile

摘要

Disclosed herein is a use of Fe_3-δO₄ nanoparticle in inhibiting the spore germination of Clostridium difficile. The Fe_3-δO₄ nanoparticle specifically targets the spores of Clostridium difficile spores by damaging and breaking the intact structure of the Clostridium difficile spores. Further, the Fe_3-δO₄ nanoparticle possesses superior sporicidal activity, as compared to other known bactericidal nanoparticles. Therefore, the Fe_3-δO₄ nanoparticle of the disclosure is useful as a bactericide or more specifically, a sporicide to treat Clostridium difficile infection for its superior sporicidal activity.