Use of Single Dendritic Wedge Cell Penetrating Peptides to Facilitate Cellular Delivery of Nanoparticles and Nanoparticles Carrying Cargos

摘要

Nanoparticles (and optionally a cargo such as a drug) can be delivered to cells by attaching just a single dendritic peptide to the nanoparticle. The dendritic peptide includes a polyhisitidine motif and a hinge and a spacer connecting the polyhistidine to a lysine-based dendritic wedge displaying at least two copies of a cell-penetrating peptide motif.