POLY-GLUTAMINE ANDROGEN RECEPTOR KNOCK-IN MOUSE MODELS, REAGENTS AND METHODS
展开▼
机译:聚谷氨酰胺雄激素受体敲入小鼠模型,试剂和方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
A knock-in non-human mammal comprising a recombinant androgen receptor (AR) cassette containing an exogenous human polyglutamine (polyQ) tract encoding sequence in exon 1, wherein the human polyQ tract encoding sequence is stably integrated into the genome of the animal. Also provided are recombinant cells, fertilized eggs and tissues. The resulting animal displays a wide range of phenotypes, best characterized as Metabolic Syndrome and can be used in screening and other assays.
展开▼