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MICROFLUIDICS BASED FETAL CELL DETECTION AND ISOLATION FOR NON-INVASIVE PRENATAL TESTING
MICROFLUIDICS BASED FETAL CELL DETECTION AND ISOLATION FOR NON-INVASIVE PRENATAL TESTING
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机译:基于微流体的胎儿细胞检测和隔离,用于无创性产前检查
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摘要
Embodiments disclosed herein provides methods for isolation of fetal cells for non-invasive prenatal diagnosis, comprising: providing a maternal blood sample; applying the maternal blood sample to a filter integrated on a microfluidic device to thereby enrich the nucleated blood cells from the maternal blood sample; labeling the enriched nucleated blood cells, within the microfluidic device, with a fluorescent binding moiety or affinity molecule that specifically binds to a fetal cell-specific antigen or a non-fetal cell-specific antigen; and isolating the fetal cells. Embodiments disclosed herein provide integrated microfluidic devices for non-invasive isolation of fetal cells, comprising: a filter; a binding moiety or affinity molecule that specifically binds to a fetal cell-specific antigen or a non-fetal cell-specific antigen; and a microscopy-visualizable chamber.
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