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METHOD FOR OPTIMAL DESIGN OF POLYNUCLEOTIDES SEQUENCES FOR ANALYSIS OF SPECIFIC EVENTS IN ANY GENETIC REGION OF INTEREST
METHOD FOR OPTIMAL DESIGN OF POLYNUCLEOTIDES SEQUENCES FOR ANALYSIS OF SPECIFIC EVENTS IN ANY GENETIC REGION OF INTEREST
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机译:用于分析任何遗传区域中特定事件的多核苷酸序列的优化设计方法
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摘要
Methods including in-silico steps for design and synthesis of Genomic Morse Code (“GMC”) probes including design of combinations of polynucleotide sequences and labelling colors for analysis of large rearrangements in targeted genetic regions as well as allele characterization of complex regions and localization of events such as replication, DNA reparation or epigenetics in particular regions. Color-encoded sets of probes that produce characteristic or unique color patterns when painted on a target nucleic acid sequence. Methods for using color-encoded sets of probes.
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