首页>
外国专利>
SELECTIVE REDUCTION OF CYSTEINE RESIDUES IN IL-17 ANTIBODIES
SELECTIVE REDUCTION OF CYSTEINE RESIDUES IN IL-17 ANTIBODIES
展开▼
机译:IL-17抗体中半胱氨酸残基的选择性还原
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present disclosure relates to methods for selectively reducing CysL97 in a preparation of IL-17 antibodies or antigen binding fragments thereof (e.g., a preparation of secukinumab antibodies) that have been recombinantly produced by mammalian cells. Also provided are purified preparations of IL-17 antibodies or antigen binding fragments thereof produced by such methods, e.g., purified preparations of secukinumab, wherein the level of intact IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 90%, as measured by sodium dodecyl sulfate capillary electrophoresis (CE-SDS), and wherein the level of activity of IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 92%, as measured by cation exchange chromatograph (CEX).
展开▼