Triple-responsive Starch-Based Microgel and Preparation Method thereof

摘要

The present disclosure discloses a triple-responsive starch-based microgel and a preparation method thereof. The present disclosure prepares C₆ oxidized starch and PNIPAM semi-interpenetrating network microgel, namely the triple-responsive starch-based microgel, mainly with pH sensitive C₆ oxidized starch and temperature sensitive NIPAM (N-isopropylacrylamide) as raw materials, and using an inverse emulsion polymerization method. The triple-responsive starch-based microgel according to the present disclosure is a spherical particle with the particle diameter of 15-25 μm, has pH, temperature and ionic strength-sensitivity, good biocompatibility and biodegradability, and can be widely used in the fields of nutrient protection, controlled drug release, protein separation and purification and the like. Meanwhile, its preparation process is simple and controllable with mild reaction conditions, and is suitable for large-scale production.