Computer-based methods and system perform root-cause analysis on an industrial process. A processor executes a hybrid first-principles and inferential model to generate KPIs for the industrial process using uploaded process data as variables. The processor selects a subset of the KPIs to represent an event occurring in the industrial process, and divides the selected data into time series. The system and methods select time intervals from the time series based on data variability and perform a cross-correlation between the loaded process variables and the selected time intervals, resulting in a cross-correlation score for each loaded process variable. Precursor candidates from the loaded process variables are selected based on the cross-correlation scores, and a strength of correlation score is obtained for each precursor candidate. The methods and system select root-cause variables from the selected precursor candidates based on the strength of correlation scores, and analyze the root-cause of the event.
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