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MODIFIED FIBROBLAST GROWTH FACTOR 1 (FGF-1) POLYPEPTIDES WITH INCREASED BINDING AFFINITY FOR HEPARIN AND ASSOCIATED METHODS
MODIFIED FIBROBLAST GROWTH FACTOR 1 (FGF-1) POLYPEPTIDES WITH INCREASED BINDING AFFINITY FOR HEPARIN AND ASSOCIATED METHODS
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机译:肝素结合亲和力增强的改良成纤维细胞生长因子1(FGF-1)多肽及相关方法
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摘要
A modified FGF-1 polypeptide that has an increased binding affinity for heparin relative the wild-type human FGF-1's binding affinity for heparin is described. The modified FGF-1 polypeptide has at least 80% amino acid sequence identity to wild-type human FGF-1 having SEQ ID NO: 1. The serine at an amino acid position of the modified FGF-1 polypeptide corresponding to amino acid position 116 of SEQ ID NO: 1 is substituted by an amino acid that increases the modified FGF-1 polypeptide's binding affinity for heparin relative to the binding affinity of SEQ ID NO: 1 to heparin.
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机译:描述了相对于野生型人FGF-1对肝素的结合亲和力增加的对肝素的结合亲和力的修饰的FGF-1多肽。修饰的FGF-1多肽与具有SEQ ID NO:1的野生型人FGF-1具有至少80%的氨基酸序列同一性。修饰的FGF-1多肽的氨基酸位置处的丝氨酸对应于氨基酸位置116相对于SEQ ID NO:1与肝素的结合亲和力,SEQ ID NO:1的Aβ被氨基酸取代,该氨基酸增加了修饰的FGF-1多肽对肝素的结合亲和力。
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