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TREATMENT VACCINE FOR PROSTATE CANCER

机译：前列腺癌治疗疫苗

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摘要

A method of treating prostate cancer by intradermally injecting a person with a composition comprising (a) a recall antigen and (b) prostate specific antigen (PSA) or peptides that are fragments of PSA is provided. The recall antigen may be Candida extract, Trichophyton antigens, or mumps antigen, or other recall antigen.

机译：提供了一种通过向人皮内注射包含以下成分的组合物治疗前列腺癌的方法，所述组合物包含（a）召回抗原和（b）前列腺特异抗原（PSA）或作为PSA片段的肽。召回抗原可能是 Candida 提取物，毛癣菌抗原或腮腺炎抗原或其他召回抗原。 展开▼

著录项

公开/公告号US2018028627A1

专利类型

公开/公告日2018-02-01

原文格式PDF

申请/专利权人 BIOVENTURES LLC;
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申请/专利号US201615552793

发明设计人 MAYUMI NAKAGAWA;AL-OLA ABDALLAH;
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申请日2016-02-26

分类号A61K39;A61K47/18;A61K9;

国家 US

入库时间 2022-08-21 13:00:48

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专利

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1. GM-CSF/TNF-α膜表面修饰的前列腺癌治疗性疫苗 [P] . 中国专利： CN101863984B . 2013.06.05

2. GM-CSF/TNF-α膜表面修饰的前列腺癌治疗性疫苗 [P] . 中国专利： CN101863984A . 2010-10-20

3. methods for determining prostate cancer susceptibility in a human individual, identifying a marker for use in prostate cancer susceptibility assessment, and for genotyping a nucleic acid sample obtained from a human individual at risk of, or diagnosed with, cancer to assess a human individual for likelihood of response to a therapeutic agent to prevent and / or ameliorate symptoms associated with prostate cancer, to predict prognosis of an individual diagnosed with cancer, and to monitor progress in treatment of an individual undergoing treatment. for prostate cancer, kit for assessing susceptibility to prostate cancer in a human individual, use of a computer readable oligonucleotide probe, and apparatus for determining a genetic indicator for prostate cancer in a human individual. [P] . BRPI0807236A2 . 2019-09-24

机译：用于确定人类个体中前列腺癌易感性，鉴定用于前列腺癌易感性评估中的标记以及对从患有癌症或被诊断患有癌症的人类个体获得的核酸样品进行基因分型以评估人类个体可能性的方法对治疗剂的反应的预防，预防和/或改善与前列腺癌有关的症状，预测诊断为癌症的个体的预后以及监测正在接受治疗的个体的治疗进展。用于前列腺癌的试剂盒，用于评估人类个体对前列腺癌的易感性的试剂盒，计算机可读寡核苷酸探针的用途以及用于确定人类个体的前列腺癌的遗传指标的设备。

4. "Prostate and prostate cancer stem cells, methods of isolating a prostate stem cell and selection of a prostate cancer patient, and methods to inhibit proliferation of a prostate stem cell, for the prevention of prostate cancer relapse, for prostate cancer treatment, for providing adjuvant therapy, for promoting growth or repair of prostate tissue, for promoting prostate growth, for functional prostate delivery, and for selecting a compound " [P] . BRPI0914473A2 . 2019-09-24

机译： “前列腺和前列腺癌干细胞，分离前列腺干细胞和选择前列腺癌患者的方法以及抑制前列腺干细胞增殖的方法，以预防前列腺癌复发，治疗前列腺癌，提供佐剂治疗，以促进前列腺组织的生长或修复，促进前列腺的生长，功能性前列腺的输送，以及选择一种化合物

5. ccr5 antagonist, method for determining whether a human individual having prostate cancer is suffering from or at risk of metastasis, to identify a ccr5 antagonist, method for determining whether a human individual having prostate cancer is suffering from or under risk of developing metastasis, to identify a candidate compound, to produce in vitro primary epithelial cells, to diagnose prostate cancer, to select a treatment for an individual having a prostate cancer / tumor, cell line, and, animal model [P] . BR112013023050A8 . 2018-09-25

机译： ccr5拮抗剂，用于确定患有前列腺癌的人是否患有转移瘤或处于转移危险中的方法，以鉴定ccr5拮抗剂，用于确定患有前列腺癌的人的个体患有转移瘤或处于转移危险中的方法，以鉴定一种候选化合物，用于产生体外原代上皮细胞，诊断前列腺癌，为患有前列腺癌/肿瘤，细胞系和动物模型的个体选择治疗方法

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2. Helping to address the over treatment of prostate cancer： tools to differentiate lethal and non-lethal phenotype in prostate cancer [J] . Professor Robert H Getzenberg, Professor H Ballentine Carter 亚洲男性学杂志：英文版 . 2012,第003期

3. Immunotherapy and therapeutic vaccines in prostate cancer:an update on current strategies and clinical implications [J] . B Harpreet Singh, James L Gulley 亚洲男性学杂志（英文版） . 2014,第003期

4. Antitumor immunity by a dendritic cell vaccine encoding secondary lymphoid chemokine and tumor lysate on murine prostate cancer [J] . Jun Lu, Qi Zhang, Chun-Min Liang, 亚洲男性学杂志（英文版） . 2008,第006期

5. Prostate cancer vaccine: A new paradigm for prostate cancer treatment [J] . Amod Kumar Dwivedi, Vengetesh K Sengottayan, Apul Goel Indian Journal of Urology: IJU: Journal of the Urological Society of India . 2011,第1期

6. A bivalent conjugate vaccine in the treatment of biochemically relapsed prostate cancer: a study of glycosylated MUC-2-KLH and Globo H-KLH conjugate vaccines given with the new semi-synthetic saponin immunological adjuvant GPI-0100 OR QS-21 [J] . Slovin SF, Ragupathi G, Fernandez C, Vaccine . 2005,第24期

7. Bivalent conjugate vaccine in the treatment of biochemically relapsed prostate cancer: a study of glycosylated MUC-2-KLH and Globo H-KLH conjugate vaccines given with the new semi-synthetic saponin immunological adjuvant GPI-0100 OR QS-21 [J] . Slovin Susan F, Ragupathi Govind, Fernandez Celina, Vaccine . 2005,第24期

8. VACCINE BASED IMMUNOTHERAPY REGIMEN FOR THE TREATMENT OF PROSTATE CANCER [C] . Helen Cho Vaccine technology VI . 2016

9. T-Cell Checkpoints, and the PD-1/L1 Pathway in Particular, are a Mode of Resistance to DNA Vaccination and Rational Combination Therapies Improve Vaccine Efficacy for the Treatment of Prostate Cancer. [D] . Rekoske, Brian. 2017

10. A vaccine strategy with multiple prostatic acid phosphatase-fused cytokines for prostate cancer treatment [O] . KEI FUJIO, MASAMI WATANABE, HIDEO UEKI, -1

11. A vaccine strategy with multiple prostatic acid phosphatase-fused cytokines for prostate cancer treatment [O] . KEI FUJIO, MASAMI WATANABE, HIDEO UEKI, 2015

12. Development of STEAP-based Vaccines for the Treatment of Prostate Cancer [R] . Garcia-Hernandez, M. 2006

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2. 宫颈癌治疗性多肽疫苗诱导出强烈的CTL效应的作用机制研究 [C] . 徐道华 ,周晨慧 ,夏永鹏 . 2006年全国生化与生物技术药物学术年会 . 2006

3. 基于PSCA的前列腺癌治疗性DNA疫苗的研究 [A] . 张晓鹏 . 2007